Education

• BSc of Pharmaceutical Sciences, Faculty of Pharmacy, Tanta University, Egypt 2001
• Master of Pharmaceutical Sciences (Pharmaceutical Chemistry), Faculty of Pharmacy, Tanta University, 2008
• PhD in Pharmaceutical Sciences (Medicinal Chemistry), School of Pharmacy, University of Mississippi, 2016

Principal Positions Held

• Community Pharmacist, Menofaia, Egypt 2001
• Pharmacist in the Egyptian Institute of Health Insurance, Shebin ELkom, Egypt, 2001-2003
• Lab Instructor and Teaching Assistant, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Tanta University, Egypt 2003-2008
• Lecturer Assistant, Pharmaceutical Chemistry Department, Faculty of Pharmacy, Tanta University, Egypt 2008-2015 (on study leave from 2011-2015)
• Research Assistant, Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, USA 2011- August 2014
• Teaching Assistant, Department of BioMolecular Sciences, Division of Medicinal Chemistry, School of Pharmacy, University of Mississippi, USA August 2014 – January 2015
• Graduate School Dissertation Fellowship, BioMolecular Sciences, Division of Medicinal Chemistry, School of Pharmacy, University of Mississippi, USA January 2015 – May 2015
• Assistant Professor, Tanta University, Egypt, June 2016 – Present

Honors and Awards

• Egyptian Syndicate of Pharmacists excellence award for pharmacy graduates 2001
• Tanta University, Egypt travel award to Ain Shams University workshop, Egypt 2004
• Thomas L. Lemke Outstanding Poster Presentation Award for best poster, Forty-First Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting in-Miniature, Memphis, TN, May 2014
• Selected to represent MS NSF EPSCoR Comp Chem in the 2015 National NSF EPSCoR meeting, Portsmouth NH (Nov 2015)
• Graduate Student Council (GSC) Research Award (2015-2016)
• UM Graduate Student Achievement Award (1 of only 2 for University of Mississippi, School of Pharmacy) (2015-2016)
• Graduate School Dissertation Fellowship (Spring 2016)
• Honor Society Memberships: Phi Kappa Phi (2013), Rho Chi (2014), Golden Key (2015), Gamma Beta Phi (2015)

Memberships

• Egyptian Syndicate of Pharmacists, Egypt 2001
• Member of American Association of Pharmaceutical Scientists 2012

Peer reviewed publications from the Doerksen Research Group

• J Bae; LE McNamara; MA Nael; RJ Doerksen; GL Bidwell III; NI Hammer; S Jo “Nitroreductase specific activatable fluorescent probe for imaging,” Chemical Communications, 51, 12787-12790 (2015). doi: 10.1039/C5CC03824C
• J Bae; MA Nael; L Jiang; PT Hwang; F Mahdi; H-W Jun; WM Elshamy; Y-D Zhou; SN Murthy; RJ Doerksen; S Jo “Quinone propionic acid-based redox-triggered polymer nanoparticles for drug delivery: Computational analysis and in vitro evaluation,” Journal of Applied Polymer Science, 131 (2014). doi: 10.1002/app.40461

Published conference abstracts while in the Doerksen Research Group

1. MA Nael; RJ Doerksen “Identification of natural products as inhibitors of the protein kinase RNA-like endoplasmic reticulum kinase to manage Alzheimer’s disease.” Planta Med. 2014, 80(10): PF10.

Conference Oral Presentations while in the Doerksen Research Group

1. SE Slater; G. Fu; MA Nael; MA Avery; RJ Doerksen “Structure-based lead optimization of a novel glycogen synthase kinase 3 beta (GSK-3β) inhibitor.” 248th American Chemical Society National Meeting, Division of Computers in Chemistry, San Francisco, CA, Aug 10-14, 2014.
2. MA Nael; RAS Gordji; J Bae; S Jo; RJ Doerksen “Prediction of paclitaxel loading into polymeric nano-systems for drug delivery.” 16th Mid-South Annual Engineering and Science Conference (MAESC 2013), University of Mississippi, Oct 2013.
3. RAS Gordji; M Nael; J Bae; S Jo; RJ Doerksen “Computational design of nanoparticles based on calculations of the optimal properties for drug delivery.” 16th Mid-South Annual Engineering and Science Conference (MAESC 2013), University of Mississippi, Oct 2013.
4. J Bae; MA Nael; F Mahdi; Y-D Zhou; RJ Doerksen; S Jo “Optimization of redox-triggered polymer nanoparticles for drug delivery via computational approaches.” 16th Mid-South Annual Engineering and Science Conference (MAESC 2013), University of Mississippi, Oct 2013.
5. MN Nael; J Bae; S Jo; RJ Doerksen “Study of a redox sensitive polymer for drug delivery.” 40th Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting, Little Rock, AR, May 2013.

Conference Poster Presentations while in the Doerksen Research Group

1. MA Nael; RJ Doerksen “Design of new inhibitors of the cyclin dependant kinase 5 (CDK5) for Alzheimer’s disease.” MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Annual Meeting, Memphis TN, Mar 2016.
2. MA Nael; RJ Doerksen “Optimization of RNA-like endoplasmic reticulum kinase (PERK) inhibitors: Thermodynamic calculations of the active site.” Mississippi NSF EPSCoR Annual Research Day @ The Capitol, Jackson MS, Feb, 2016.
3. MA Nael; RJ Doerksen “Virtual screening of new inhibitors of the protein kinase RNA-like endoplasmic reticulum kinase (PERK).” 2015 American Association of Pharmaceutical Scientist (AAPS) Annual Meeting and Exposition, Orlando, FL, Oct 27, 2015.
4. MA Nael; RJ Doerksen “Insights into optimal design of protein kinase inhibitors: Role of waters in the binding site.” 24^th National NSF (National Science Foundation) EPSCoR Conference, Portsmouth, NH, Oct 2015.
5. MA Nael; RJ Doerksen “Design of multiple-kinase inhibitors to manage Alzheimer’s disease.” University of Mississippi School of Pharmacy Annual Poster Session, Oxford, MS, Oct 2, 2015.
6. RJ Doerksen, KK Roy, MA Nael, P Pandey “Computational medicinal chemistry capabilities and accomplishments.” University of Mississippi School of Pharmacy Annual Poster Session, Oxford, MS, Oct 2, 2015.
7. J Bae; LE McNamara; MA Nael; F Mahdi; RJD; GL Bidwell; NI Hammer; S Jo “Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue.” University of Mississippi School of Pharmacy Annual Poster Session, Oxford, MS, Oct 2, 2015.
8. EA Peralta; E Ferreira; M Nael; RJ Doerksen “Docking studies of manzamine A and manzamine 8-OH in the Mycobacterium tuberculosis shikimate kinase.” Universidad La Salle Pharmacobiology Chemistry Program Poster Day, Mexico City, Mexico, Sep 2015.
9. MA Nael; RJ Doerksen “Design of new inhibitors of the protein kinase RNA-like endoplasmic reticulum kinase (PERK).” Drug Discovery and Development Colloquium 2015, Oxford, MS, Jun 2015.
10. MA Nael; RJ Doerksen “Binding of bryostatin 1 to the C1B domain of protein kinase C epsilon (PKC-ε).” 8th Annual Mississippi Biophysical Consortium 2015 Annual Meeting, Oxford, MS, Jun 2015.
11. MA Nael; RJ Doerksen “Targeting protein kinase C epsilon (PKC-ε) to manage Alzheimer’s disease.” 42^nd Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting, Oxford, MS, May 2015.
12. V Gadepalli; MA Nael; RJ Doerksen “3D analysis and selective targeting of ERK2/caspase-9 interaction for the development of probes to suppress caspase-9 activation.” 42^nd Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting, Oxford, MS, May 2015.
13. SE Slater; KK Roy; J Kollar; MA Nael; KM Elokely; RJ Doerksen; MA Avery “Determining alternative artemisinin binding sites in PfSERCA.” MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Annual Meeting in Little Rock, AR, Mar 2015. Shuneize Slater won First Place Graduate Student Biological Bioinformatics Poster Presentation.
14. MA Nael; SE Slater; RJ Doerksen “Analysis of water molecules in the active site of the protein kinase RNA-like Endoplasmic Reticulum Kinase (PERK): Insights for lead optimization.” Southeastern Regional Meeting of the American Chemical Society (SERMACS) 2014, Nashville, TN, Nov 2014.
15. J Bae; MA Nael; L Jiang, PT Hwang, F Mahdi; HW Jun; WM Elshamy; YD Zhou; SN Murthy; RJ Doerksen; S Jo “Quinone propionic acid-based redox-sensitive polymer nanoparticles for controlled drug delivery.” American Association of Pharmaceutical Scientist (AAPS) Annual Meeting and Exposition, San Diego, CA, Oct 2014.
16. MA Nael; RJ Doerksen “Identification of natural products as inhibitors of the protein kinase RNA-like endoplasmic reticulum kinase to manage Alzheimer’s disease.” American Society of Pharmacognosy 2014 Annual Meeting, Oxford, MS, Aug 2014.
17. MA Nael; RJ Doerksen “Targeting protein kinase RNA-like endoplasmic reticulum kinase to manage Alzheimer’s disease.” 41^st Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting, Memphis, TN, May 2014.
18. S Slater; G. Fu; M Nael; MA Avery; RJ Doerksen “Identification of novel phthalimide inhibitors of GSK-3B: A computational study.” 41^st Annual MALTO Medicinal Chemistry-Pharmacognosy Meeting, Memphis, TN, May 2014.
19. S Slater; G Fu; MA Nael; MA Avery; RJ Doerksen “Development of novel phthalimide inhibitors of glycogen synthase kinase-3 beta (GSK-3β).” University of Mississippi Graduate Student Council Research Forum Poster Competition, Oxford, MS, Apr 2014. Shuneize Slater won 2^nd place.
20. MA Nael; J Bae; RAS Gordji; S Jo; RJ Doerksen “Prediction of hydrophobic drug loading into polymeric micelles for drug delivery.” Mississippi National Science Foundation (NSF) EPSCoR Annual Meeting, Starkville, MS, Mar 2014.
21. J Bae; MA Nael; F Mahdi; Y Zhou; RJ Doerksen; S Jo “Redox-responsive polymeric nanoparticles for cytotoxic drug delivery via computational approaches.” 17th Annual University of Mississippi School of Pharmacy National Center for Natural Products Research Poster Day, Nov 2013.
22. MN Nael; J Bae; S Jo; RJ Doerksen “Prediction of paclitaxel loading into amphiphilic block copolymers comprised of polyethylene glycol and redox-sensitive polyester with pendant trimethyl-locked quinone propionate.” Mississippi NSF EPSCoR Annual Meeting, Hattiesburg, MS, Apr 2013.
23. J Bae; MA Nael; F Mahdi; Y-D Zhou; RJ Doerksen; S Jo “Optimization of trimethyl-lock quinone propionic acid-based redox-sentitive polymer nanoparticles for drug delivery application.” Mississippi NSF EPSCoR Annual Meeting, Hattiesburg, MS, Apr 2013.
24. MN Nael; J Bae; S Jo; RJ Doerksen “Modeling of trimethyl-locked quinone based polymers for drug delivery.” SOP/NCNPR Annual Research Day, University of Mississippi, MS, Nov 2012.
25. J Bae; MA Nael; RJ Doerksen; S Jo “Trimethyl-locked benzoquinone based polymeric nanoparticles for targeted drug delivery.” American Association of Pharmaceutical Scientist (AAPS) Annual Meeting and Exposition, Chicago, IL, Oct 2012.
26. J Bae; MA Nael; JM Anderson; RJ Doerksen; H-W Jun; S Jo “Novel redox-sensitive polymeric nanoparticles for targeted delivery of anti-cancer agents.” 5th Annual Mississippi Biophysical Consortium Annual Meeting, Hattiesburg, MS, Jun 21-22, 2012.
27. J Bae; MA Nael; RJ Doerksen; S Jo “Redox-sensitive polymeric nanoparticles for targeted cancer drug delivery.” Mississippi NSF EPSCoR Annual Meeting, Oxford, MS, Apr 2012.
28. MA Nael; J Bae; S Jo; RJ Doerksen “Modeling of trimethyl-locked quinone based polymers for drug delivery.” Mississippi NSF EPSCoR Annual Meeting, Oxford, MS, Apr 2012.